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Actigraphic evidence and polysomnography studies have detected higher density of REM sleep, greater variability in sleep patterns, longer sleep latency and duration, lower sleep efficiency, greater number of arousals, fragmented sleep, and reduced daily activity, both in actively ill and remitted bipolar patients, relative to healthy controls (181184)

The 4 candidate biomarkers identified in this work were present in blood, an accessible and relevant biological compartment for diagnostic test development

Molecules , 22 , 1560

Some of the polar groups also serve as hydrogen acceptors (O, ethers, carbonyls, ketones, aldehydes, acids, esters, amides, and amine nitrogens) or as hydrogen donors (NH, amines, amides, and thiols/SH)