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68 Similarly, the link between PD and the braingutmicrobiome axis is hotly debated: the gutfirst hypothesis proposes that gut microbial dysbiosis may trigger neurodegeneration via the vagus nerve or immune system, which is quite compelling, whereas interestingly, the brainfirst hypothesis suggests that brain pathology (e.g., -synuclein aggregation) may occur first and affect the gut microbiota

Metabolism and disposition of [(14)C]tivantinib after oral administration to humans, dogs and rats

doi: 10.1016/j.msec.2019.04.064 152 YeoIL

"We had seen potential for CagriSema to demonstrate superior weight loss to Zepbound given the amylin component