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So if someone is low in B12 and they consume alcohol, they not only don't have enough B12 to help 'clear away' the alcohol toxins but they also risk increasing homocysteine levels which I believe is that feeling of heat/hangover that can persist when there isn't enough B12 to reset the body

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An enzyme called NNMT (nicotinamide N-methyltransferase) drains the NAD+ salvage pathway by methylating nicotinamide, one of NAD+'s precursors

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Extracellular regulated kinase phosphorylates mitofusin 1 to control mitochondrial morphology and apoptosis