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The clinical laboratory can detect phenotypic features consistent with this dysfunctional state by measuring the co-expression of inhibitory receptors, for example PD-1 bright TIM-3 + T cells, using multi-parametric flow cytometry (53)

Diffraction data were collected at the Swiss Light Source (Paul Scherrer Institut, Villigen AG) on beamline X06DA-PXIII at a temperature of 100 K and 0.999995 wavelength using the serial synchroton crystallography software suite

Lagier-Tourenne C, Polymenidou M, Hutt KR, Vu AQ, Baughn M, Huelga SC, et al

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