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Half of the sample was used for this protocol and half were pelleted and snap-frozen for nuclear extraction described below

These differences may be explained by numerous factors, such as variable disease prevalence in select populations

For example, cuprizone administration reduces the mitochondrial enzymes monoamine oxidase (as early as 3 days [27]) and cyt c oxidase [28, 29] in the brain of mice, both of which require copper for catalysis [126]

38 (International Pediatric Research Foundation, Inc, 1995)

This is the reason why drugs that are orally administered as sustained-release, extended-release, or other time-release formulations have an artificially lengthened half-life