melanotic macule causes Mystery behind labial and oral macules: Clinical, dermoscopic and pathological aspects of Laugier-Hunziker syndrome Mucosal melanocytic macules

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Kucera, P., Goldenberg, Z., Varsik, P., Buranova, D

ccRCC exemplifies this complexity: HIF-2 stabilization induces glycolysis via pyruvate dehydrogenase kinase (PDK)-mediated suppression of oxidative phosphorylation (OXPHOS), while simultaneously upregulating glutamine transporters to fuel reductive carboxylationa metabolic bypass sustaining lipid biosynthesis under hypoxia [19, 20]

Immune or clearance burden: a rapid wave of dying cells must be cleared, which could stress the system

2023;16(8):dmm050170