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In wildtype mice, optogenetic inhibition of GABAergic interneurons in the medial prefrontal cortex (mPFC) leads to cognitive deficits ( +/ ) or absent (PV / ) expression exhibit the core ASD-like symptoms ( In addition, Reelin is an extracellular matrix glycoprotein closely related to neural development, which is involved in the regulation of neuronal migration, synaptic plasticity and neural network formation ( 3.2 The relationship between GABAergic signaling pathway abnormalities and ASD 3.2.1 The synthesis, release, transport, and metabolism of GABA The biosynthesis of GABA primarily relies on the decarboxylation of glutamate catalyzed by GAD

However, the formation of the cysteine-aldimine/cysteine-quinonoid still occurred at 4 C (Table 2 and Supplementary Fig

Elevated superoxide can combine with NO, resulting in the formation of the peroxynitrite radical and the protein oxidative damage biomarker, 3-NT

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