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This modification appears early in the G2 phase within pericentromeric heterochromatin and spreads, coinciding with mitotic chromosome condensation

Analysis of Apoptosis and DNA-Cell Cycle by Flow Cytometry Cell suspensions from specimens were collected from the stomach mucosa of rats treated with honey and from the control were treated with 0.1% Triton X-100 to create pores in cell membrane to allow the penetration of Propidium Iodide stain into the cell

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As stated previously, those studies ascribe in probiotics properties such as, anti-carcinogenic effect, anti-mutagenic effect, derangement in differentiation process in tumor cells, modifications of tumor gene-expressions, inhibition of pro-carcinogenic bacteria and improvement of the immune system and intestinal balance (206)