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Cysteine-directed activity-based protein profiling (ABPP) To determine the specific site of DJX-A-KM with the E3 ubiquitin ligase FBXO28 during KRAS G12C degradation in living cells, we used cysteine-directed activity-based protein profiling (ABPP) to quantify cysteine modified by DJX-A-KM , iodoacetamide (lAA) alkyne probe was used as a tool probe