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Other key limitations are delivery bottlenecks, specifically the failure to cover the extensive dopaminergic axonal network, and reduced Ret expression in neurons of advanced PD patients

Within the autophagy pathway, the interplay of PTEN-induced putative kinase 1 (PINK1) and Parkin proteins is crucial in mitochondrial autophagy regulation

Starting with lower doses and gradually increasing helps minimize these effects

The SSTR2-binding octreotide was conjugated to doxorubicin via a cleavable disulfide bond and used for the treatment of pituitary, pancreatic, and breast tumors 78

The authors reported the expression of FLIPmal in yeast cells, and measured the changes in the concentration of maltose by ratiometric imaging 26