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In addition, A phased approach to microbiometargeted therapy in ICU patients is proposed

Maher JJ

Critical limitations identified in the systematic review include predominant use of small rodent models (primarily rats), short follow-up periods relative to human healing timelines, variable dosing regimens complicating dose-response assessment, and lack of standardized outcome measures across studies

Keck PE Jr, Mintz J, McElroy SL, Freeman MP, Suppes T, Frye MA, Altshuler LL, Kupka R, Nolen WA, Leverich GS, Denicoff KD, Grunze H, Duan N, Post RM (2006) Double-blind, randomized, placebo-controlled trials of ethyl-eicosapentanoate in the treatment of bipolar depression and rapid cycling bipolar disorder

As this field is rapidly evolving, and a growing number of studies support the notion that alterations in the microbiome and disease-specific pathologies occur several years before the onset of neurodegeneration, a more refined diagnostic procedure and development of novel intervention strategies (e.g., microbiome-based therapeutics) targeting the microbiome will greatly benefit translational discovery efforts in neurodegeneration