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The tumor necrosis factor (TNF) receptor superfamily, such as Fas and TNF-related apoptosis-inducing ligand (TRAIL) receptors, TNF receptors (TNFR), and Fas (CD95), plays a crucial role in the extrinsic pathway [73,74]

identified that ATO effectiveness in non-APL AML is often limited because ROS upregulation alone is insufficient to trigger death in resistant clones [315]