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Additionally, mechanistic studies further demonstrated that KD modulates inflammatory signaling pathways in EAE models, including reducing NF-B activation and decreasing NLRP3 inflammasome activity, alongside improvements in motor outcomes [116]

& Collins, M

Animal models can be further used to explore the role of prebiotics and probiotics on cognition and behavior, including changes in depression, anxiety, and stress associated with changes in immune markers, hippocampal synaptic efficacy, and tryptophan metabolism (376, 387)

This has not been replicated in humans, however, and as such, it remains to be confirmed if this mechanism occurs during human exercise