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Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index

Triglycerides are resynthesized in the enterocyte and packaged into chylomicrons

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The cerebrovasculature is a very bioenergetically active tissue with capillary endothelial cells having been shown to possess five times more mitochondria than muscle cells (Oldendorf and Brown, 1975) and transport 10 times their weight in glucose each minute across the BBB, along with accomplishing other energetically costly cellular processes (Cunnane et al., 2011)