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Patients also typically have hand numbness in at least the ring finger and small finger

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In vivo studies used intraperitoneal doses ranging from 1 to 30 mg/kg, with lower doses (15 mg/kg) primarily associated with neurochemical modulation [14, 15, 17], whereas higher or repeated dosing ( 2030 mg/kg) was more frequently linked to withdrawal-associated molecular, proteomic, and epigenetic changes [24, 26, 27]