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It disrupts the pattern the protocol is designed around

Circulating levels of sKlotho are markedly increased in acromegalic patients and return to normal in parallel with GH and IGF-1 levels after tumor removal [111, 112]

Beck and colleagues reported in 2014 that the 117-patient proof-of-concept study found ipamorelin well tolerated but did not reach statistical significance on its primary composite gastrointestinal endpoint at the studied dose

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