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27 In non-severe patients, cytokine levels, including IL-1, IL-1RA, IL-2R, IL-6, IL-7, IL-8, IL-9, IL-10, IFN-, TNF-, G-CSF, GM-CSF, IP10, MCP1, are also upregulated in the blood 2,12,22 but are significantly lower than those in severe patients

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A randomized, phase 1, placebo-controlled trial of APG-157 in oral cancer demonstrates systemic absorption and an inhibitory effect on cytokines and tumor-associated microbes

6 In transsulfuration pathway, methionine reacts with ATP to form S-adenosine methionine (SAM) under the catalysis of methionine adenosine transferase I/II (MAT1A/MAT2A)