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During the progression of PF, various induction factors, such as cigarette smoke [25], bleomycin (BLM) [24], paraquat (PQ) [26], silicosis [27], and PM2.5 [28], have been shown to trigger the initiation of ferroptosis, leading to fibroblast-to-myofibroblast differentiation and pro-fibrotic factors release

It acts as a powerful antioxidant, helping to neutralize free radicals and support cellular health

PubMed PMID: 30727890

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Then, the in vivo pharmacokinetics of free aPD-L1 and A2-APM were examined to investigate their transportability in the vasculature (Supplementary Fig