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The observation that patients with AD carrying two alleles of the APOE4 risk variant have approximately half the cerebrospinal fluid (CSF) melatonin levels compared to those with only one allele of this variant [75] could suggests that APOE4/4 carriers might particularly benefit from supplementing with exogenous melatonin

Dihexa half life (one to three hours) measures the time required for plasma concentrations to decline by 50%, while therapeutic window refers to the duration during which receptor activation drives neuroplasticity changes which extends for hours beyond plasma clearance

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Future studies should explore and develop new research models containing complex disease-syndrome combinations to be in line with the current majority clinical practice

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