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As a secreted protein, MANF can be easily detected in serum, highlighting its potential as a non-invasive biomarker for the early diagnosis of ICC

Expectations should be adjusted accordingly, with longer protocol durations (8 to 12 weeks), potentially higher doses, and understanding that improvement may reach 70 to 90 percent of normal rather than complete resolution

Activation of Atg7-dependent autophagy by a novel inhibitor of the Keap1-Nrf2 protein-protein interaction from Penthorum Chinense Pursh

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Glutathione synthesis is diminished in patients with uncontrolled diabetes and restored by dietary supplementation with cysteine and glycine. Diabetes Care