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They have a similar structure, as for the functions, DNMT3a tends to be ubiquitously expressed and it is important for cell differentiation and maternal imprinting, while DNMT3b has a low expression in differentiated tissues, except for bone marrow, testes and the thyroid gland, and it is crucial in early development and X-chromosome inactivation in females [12, 18]

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Fibrosis was further assessed by bronchoalveolar lavage cell counts and histology evaluation

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