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In an alternative embodiment, the ability of a test compound to modulate the activity of a biomarker of interest (e.g., one or more targets listed in table 1 and/or table 2) can be determined as described above for cell-based assays, e.g., by determining the ability of a test compound to modulate the activity of a polypeptide that acts downstream of the polypeptide

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NRF2 is a key regulator of endothelial microRNA expression under proatherogenic stimuli