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4,7-12 The shifting therapeutic landscape of emerging agents is already impacting current real-world use, as further discussed in subsequent sections

98,99 Then, the hydrophobic C-terminal of AMP may insert into the hydrophobic region of the cell membrane, which may change the conformation of the cell membrane and reduce the activity of P-gp by inhibiting the efflux of chemotherapy drugs, increasing the intracellular drug concentration, and reversing drug resistance of MDR tumor cells