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A Novel Fc-FGF21 With Improved Resistance to Proteolysis, Increased Affinity Toward -Klotho, and Enhanced Efficacy in Mice and Cynomolgus Monkeys

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No mixed disulfide intermediate was detected in accordance with a slow reaction between both proteins that was followed by a rapid intramolecular disulfide bond formation yielding roGFP2 WT (S 2 )

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