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We measured ROS levels in N41 cells treated with AA, DHA or TA for 4 h in the presence or absence of GSH-MEE

This forceful action can damage the peptide molecules

Additionally, Nrf2 knockout lead to the formation of fibrotic tissues, indicating that Nrf2 is a potential ferroptosis-related therapeutic target and biomarker for evaluating the severity of PF [215]

Many registered phase I/II clinical trials designed to investigate the effectiveness of curcumin alone or with first-line treatment in patients with breast, prostate, pancreatic, lung, or colorectal cancer are under way (69)

The first reason is based on their LD 50 , which was reported to be 5000 mg/kg bwt for both MC and CBZ and 3000 mg/kg bwt for HML 31,32