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The few available human studies are small, unblinded, and often conducted by clinics with a stake in the outcome

These therapies aim to enhance WL and improve metabolic outcomes by engaging multiple hormonal pathways, with preclinical and early-phase clinical trials supporting their potential as next-generation obesity treatments [16,17,18,19,20,21,22,23]

Matsuzawa noted that the major difference in pathologies observed was increased septicemia in mice from the conventionally housed heme/GI group and later appearance of diarrhea in the GI group

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