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Link Dhingra, D., et al

These symptoms most often include: Paresthesia: Numbness, itching, burning, or tingling in the limbs or other parts of the body Ataxia: impaired coordination, balance, and speech Myelopathy: pain in the neck or back and tingling, numbness, or weakness in the limbs The occurrence of these conditions in people with vitamin B12 deficiency is due to the role of vitamin B12 in preventing nerve damage and ensuring efficient transmission of nerve impulses

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But in practice, and especially with regard to synthetic and recombinant peptide forms, there are some considerable potential safety concerns: Immunogenicity Most notably, per a 2020 assessment on therapeutic peptide safety, synthetic and recombinant peptides pose the risk of immunogenicity the ability of a substance to provoke an immune response.15 An immunogenicity-inducing peptide, when introduced to the body, would cause the bodys immune system to perceive the peptide not as a medication but as a threat