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An enormous challenge in such animal models is to establish the relevance of the mechanisms elucidated to OCD in humans

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Pathway analysis of siGSTO1 Bru-Seq data was also performed using IPA (Ingenuity Systems, Inc., Redwood City, CA) with genes showing fold change 2

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Inhibition of 25-OHC expression or treatment with Fer-1, a ferroptosis inhibitor, significantly suppressed ferroptosis and lipid peroxidation in IMS32 cells and alleviated neurological damage, indicating that 25-OHC may serve as a potential therapeutic target for ALS (Urano et al., 2025)