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The resulting acetoxyarylamines are highly unstable, spontaneously forming arylnitrenium ions that bind to DNA (Bland & Kadlubar, 1985) and ultimately lead to mutagenesis and carcinogenesis (Kerdar et al., 1993)

In the future, considerable effort will be needed to characterize the interactions of these epigenetic marks with metabolic reprogramming factors in cancer cells

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Drug combination studies showed that NBDHEX is significantly active on cisplatin-resistant human osteosarcoma cells 77

The clinical success of iron chelation in this context validated the principle of targeting toxic iron overload