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Silencing p53 significantly alleviated PMB-induced iron accumulation and lipid peroxidation, increased the expression of TFR1 and ALOX12, and decreased the expression of GPX4 and SLC7A11 [178]

(PubMed) Kauwell GP, Wilsky CE, Cerda JJ, et al

The results illustrate the potential of a mechanism-guided therapeutic strategy by targeting a metabolic vulnerability in the ferroptosis of CSCs to improve the efficacy of lung cancer immunotherapy