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Studies (42, 43) have shown that apigenin has a pro-apoptotic effect in human RA-FLS, and it can induce RA-FLS apoptosis by mediating ROS and oxidative stress activator ERK1/2, and mediate apoptotic cell death by activating the apoptotic effector caspase-3/7

Am J Dis Child

The underlying clinical question has not changed

Pediatr Res 70(3):272277 Garberg HT, Huun MU, Escobar J, Martinez-Orgado J, Loberg EM, Solberg R, Didrik Saugstad O (2016) Short-term effects of cannabidiol after global hypoxia-ischemia in newborn piglets