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Shaking introduces significant mechanical stress and can cause shearing forces that break the delicate amino acid bonds of the peptide

They'll be much bigger and shaped differently than healthy ones

This is not simply due to supplements but also due to the widespread fortification of foods with folic acid and has been shown by some authors to lower the rates of macrocytosis in patients with proven B12 deficiency (Wyckoff)

Better tools and standards to diagnose B12 deficiencies are needed to make specific recommendations about the appropriateness of vitamin B12 supplements for younger adults [51]

[Google Scholar] 102.Tremblay A., Prusse L., Bouchard C