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HFS (of all grades) occurred in ~50% of patients in the early phase II studies of capecitabine as a single-agent therapy for metastatic breast and colorectal cancers, with 10% of patients experiencing severe HFS (grade 3) (3)

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Questions remaining include optimal human dosing, long-term safety, effects across different populations, interactions with diet and exercise, and whether benefits extend beyond weight loss to improvements in cardiometabolic disease outcomes

doi: 10.3390/nu12030726 188 TsengP.-H.ChaoC.-C.ChengY.-Y.ChenC.-C.YangP.-H.YangW.-K.et al