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Although prospective or randomized designs provide stronger control over confounding factors, logistical constraints and ethical considerations limited their feasibility in this setting

The consequences seem to be highly dependent on the degree of L-glu increase but even a 10% increase appears to affect nerve cell structure and survival particularly in the context of aging suggesting that chronic excitotoxicity may be particularly relevant to age-related neurodegenerative diseases

Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1

Dig Dis Sci 69 , 33443360 (2024)

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