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Weight loss caused circulating ghrelin levels to rise in two studies (521,522)

10.1371/journal.pone.0145790 136 WenS.-w.ZhangY.-f.LiY.XuY.-z.LiZ.-h.LH.et al (2018)

doi: 10.1016/j.phrs.2023.106918 135 ChenYHuangGQinTZhangZWangHXuYet al

Therefore, the use of these medications is restricted in certain populations, such as pregnant women, the elderly, and individuals in specific high-risk occupations, including pilots, athletes, law enforcement officers, and military personnel, due to their potential adverse effects