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For JMV2959, there are a few cases in the literature where there is an effect of JMV2959 on baseline locomotion, albeit the effect is mild and transient

doi: 10.1016/S1474-4422(08)70092-9 10

DPSC injection resulted in greater improvement in BDD (0.30 0.484 mm) compared to saline injection (0.04 0.315 mm)

Accordingly, the SLC1A2 gene that encodes the astrocytic excitatory amino acid transporter 2 (EAAT2, responsible for majority of glutamate re-uptake in the brain) is a susceptibility locus to BD (Fiorentino et al., A relationship was found between glucose metabolism and glutamatergic neuronal function in vivo in the rat cortex by measuring the rates of TCA cycle and glutamate synthesis using 14 C-MRS (Sibson et al., 1998)

Neuropsychiatry Clin