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The cognitive load, the pace, the constant decision-making and the pressure of being "on" all day were simply too much

[PubMed: 6500232] Hall LN, Sanchez LR, Hubbard J, Lee H, Looby SE, Srinivasa S, et al

IGF-1 metabolic actions are partly directed at stimulating the uptake of glucose, fatty acids, and amino acids so that metabolism supports growing tissues

Bowman CJ, Ayer DE, Dynlacht BD

This mechanism may be primarily caused by the deregulation of the Ca 2+ homeostasis induced by the mutation in PSEN1 , as described in PSEN1 mutant AD iPSC-derived astrocytes (Oksanen et al., 2017)