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Research analyses have indicated that middle-aged individuals, men, those with obesity, individuals with low magnesium intake, and patients with depression are more prone to sleep problems and sleep disorders

Orian, R

doi: 10.1016/j.semcdb.2007.09.003 91 MartiniT.RippergerJ

When IGF-1 LR3 binds to IGF-1R, it triggers autophosphorylation of intracellular tyrosine residues, recruiting insulin receptor substrate-1 (IRS-1) and activating downstream PI3K/Akt and MAPK/ERK pathways