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Takeura et al., 2019

Am J Physiol Lung Cell Mol Physiol 310(9):L837L845 Nie Z, Jacoby DB, Fryer AD (2014) Hyperinsulinemia potentiates airway responsiveness to parasympathetic nerve stimulation in obese rats

J Psychiatr Res 44(13):808816

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Key Takeaways G-protein-coupled receptors rely on the activation of G-proteins to cause cellular changes G-protein-coupled receptors have slower effects than ligand-gated receptors G-proteins can open ion channels, alter protein function via phosphorylation, and alter gene transcription The G s subunit initiates the adenylyl cyclase / cAMP signaling pathway The G i subunit inhibits the adenylyl cyclase / cAMP signaling pathway The G q subunit initiates the phospholipase C / IP 3 / DAG signaling pathway Test Yourself