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Intestinal stem cells (ISCs), which reside at the base of the crypt, have the ability to self-renew and to generate the lineages that make up the intestinal epithelium

The main limitations of that study included the small sample size, open-label design, and absence of concomitant rifaximin use, which is known to reduce short-term mortality

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Importantly, these findings led to a clinical trial testing the efficacy and safety of statins in RTT patients (NCT02563860)