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2025 Jul:84:103693

In the same tumor type, LDHA, is downregulated by miR-34a-5p, together with PKM2

In fact, most clinicians interpret depression as a monoamine neurotransmitter imbalance, making serotonin, dopamine and/or adrenaline the primary targets for most conventional first-line antidepressant treatments

Exercise has been known to attenuate oxidative stress and improve diabetic complications due to its effects on mitochondrial carbohydrate and lipid metabolism ( Our earlier study on GK rats subjected to moderate exercise training has shown improvement in cardiac muscle contractile dysfunction and relaxation in myocytes, which are relevant to improvement in diabetes-induced myocardial dysfunction ( Exercise training is recognized as an important non-therapeutic strategy in the management of type 2 diabetes, and studies have shown its effects on mitochondrial metabolic, oxidative, and redox functions in different tissues

Adapted from Maninova and Vomastek, 2016 [60]