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The main difference is that Retatrutide is a triple-agonist, targeting GLP-1, GIP, and the Glucagon receptors

doi: 10.1016/j.cellsig.2018.08.019 67 FruhS

Further beneficial probiotic effects include strong enzymatic activity against proteins, lipids, and carbohydrates to assist in food digestion, and the generation of various biomolecules known to be important in nutrient absorption