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Similarly, fisetin, a flavonoid found in strawberries and other fruits, activates SIRT1 by increasing NAD + levels while also reducing oxidative stress and inflammation 179 (Fig

Moving forward, efforts should be made to develop a molecular network landscape of magnesium-mediated sleep regulation using multi-omics approaches (eg, transcriptomics and metabolomics), aiming to elucidate the interactive mechanisms across neurotransmitter, endocrine, and immune pathways

Ethanol is the main substrate for alcohol dehydrogenase, but its oxidation is efficient only in reaction catalyzed by isoenzymes class I and IV