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If you have variants that slow your methylation cycle (MTHFR, COMT, DNMT polymorphisms), your ability to respond to and recover from epigenetic disruption is already compromised

Scientific Reports (2020) 4

J Physiol (Paris) 2001

3.3 Pro-senescence therapy The concept of anticancer therapy where the induction of senescence is the main therapeutic goal has been accompanying us for over a dozen years [8]

However, in mice pretreated with AcSDKP, CFU-GM recovery was significantly improved on days 7 and 11, particularly when AcSDKP was given 48 hours before DOX rather than 24 hours