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In a study of 156 patients with CHF, in which all patients were given conventional medications for the disease, those who were also given 1.2-2 g of berberine per day experienced improvements in ejection fraction, exercise capacity, and dyspnea, as well as a decrease in the frequency of complex premature ventricular contractions (PVCs), compared to the placebo group

20 Antioxidant-enzyme interaction Free radicals are continuously produced during cellular metabolism

Biochem Biophys Res Commun 524(4):895902 Gureev A, Krutskikh E (2025) Regulation of the NRF2 transcription factor activity by SIRT1-induced deacetylation: a possible SIRT1NRF2 feedback loop