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Thus, the in vitro maturation rate of mouse oocytes could significantly decrease, which might be one of the causes of endometriosis-related infertility [89]

Immunogenicity is reduced in drugs based on human protein sequences, but these are more difficult to develop as they may lack efficacy in animal models

doi: 10.3389/fimmu.2025.1631074 Received 19 May 2025 Accepted 30 September 2025 Published 15 October 2025 Volume 16 - 2025 Edited by Liliana Gabriela Popa, Carol Davila University of Medicine and Pharmacy, Romania Reviewed by Mauro Alaibac, University of Padua, Italy Tetsuro Kobayashi, Riken Yokohama, Japan Updates Copyright 2025 Wang, Cao, Liu, Xiong, Xu and Bian