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Our findings suggest that BDFs anticonstipation effects are dose-dependent, with high doses significantly improving outcomes, including fecal count, water content, and propulsion rate

doi: 10.1046/j.1432-1327.1999.00646.x Fletcher, Jamie I., Dingley, Andrew J., Smith, Ross, Connor, Mark, Christie, MacDonald J

These data support a normal role for insulin signaling, as a determinant of chondrocyte size, which is apparently cannot compensated by local upregulation of IGF-1/IGF-1R