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and Park et al

The AT 1a receptors possess two sets of disulfide bridges at the extracellular domain of the receptors: C18-C274 and C101-C180

These gaps create challenges for complex multi-drug nano-formulations used in HIV therapy, which require additional scrutiny for stability, drugdrug interactions, and clinical endpoints

Biomarkers and titration Titration should follow a composite, compartment-aware panel that pairs species/flux readouts with cumulative damage footprints, buffer status, iron/ferroptosis metrics and functional endpoints