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Moreover, UV radiation can activate the proopiomelanocortin (POMC) gene and thereby enhance the production of alpha-melanocyte stimulating hormone (-MSH) and adrenocorticotropic hormone (ACTH) which can lead to increased PKA and melanogenesis (Im et al., 2002)

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2001 doi: 10.1001/archsurg.136.10.1201

Typical protocol structure: Dose: 100-200mcg based on individual response Frequency: 3-5 times per week Timing: 1-3 hours before bed (experiment to find your optimal window) Cycle length: 4-8 weeks Break period: 2-4 weeks between cycles The frequency debate generates significant discussion

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