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Description

Allegra E, et al

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Although it is not possible at this stage to identify the mechanisms at the basis of the upregulation of mitochondrial respiration promoted by the presence of the TDP-43 G376D , it is likely that the increased amount of ATP required by the cells to counteract the effect of the mutation drives the upregulation of mitochondrial respiration

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Their results are crucial for pharmacodynamics, pharmacokinetic, and toxicological research

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W.PawelB

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doi: 10.1016/j.cell.2014.12.019 105 SteynACrowtherNJNorrisSARabionetREstivillXRamsayM

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